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KMID : 0984920080100020050
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Journal of Skin Barrier Research
2008 Volume.10 No. 2 p.50 ~ p.50
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The association between clinical scoring and noninvasive instrumental assessment of skin barrier functions of the patients with atopic dermatitis
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Kang Ju-Hyun
Kim Sang-Hyun
Seo Jong-Keun
Lee Deborah
Sung Ho-Suk
Hwang Seon-Wook
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Abstract
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Atopic dermatitis(AD) is a chronic relapsing inflammatory skin disease characterized by dry skin, pruritus, and typical distribution of the lesions. Although various factors including genetic and immunological factors are known to play roles, the pathogenesis of AD is incompletely understood. Recently underlying defects in skin barrier function are also considered to be important in the pathogenesis of AD. Although there is no gold standard methods to assess the severity of AD, the SCORAD index is a validated clinical scoring tool composed of objective and subjective criteria. On the
other hands, transepidermal water loss(TEWL) and skin hydration(SH), biophysical methods to evaluate the integrity of skin barrier, provide objective scores obtained by the noninvasive instruments. TEWL indicate the rate of migrating water from viable tissue through the layer of stratum corneum to the external environment. SH is quantified arbitrary units that the relative hydration of the stratum corneum. The SCORAD index, TEWL, and SH were used in many studies associated with AD, but there are few studies to evaluate of the association between clinical scoring and noninvasive instrumental assessment of disease severity. In our study, we measured SCORAD index and noninvasive instrumental assessment in the lesional and non-lesional skin of forty-four patients with atopic dermatitis. There were significant correlations
between clinical scoring and noninvasive measured values. Assessment of disease severity using both instrumental measures and clinical scoring may therefore, be more reliable tools over either method alone.
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KEYWORD
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atopic dermatitis, non-invasive measures, transepidermal water Loss, SCORAD index
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